Team-Based Learning (TBL) is a special form of collaborative learning that engages students with course content via problem-solving and decision-making using a specific sequence of individual work, group work and immediate feedback. TBL creates a motivational framework in which students increasingly hold each other accountable for coming to class prepared and contributing to active discussion. In this session we will explore how and why TBL works, and summarize findings from the education literature with evidence of improved learning using TBL in the health sciences.